ACE2: A New Target for Prevention of Diabetic Nephropathy?

[摘要] Abundant, well-accepted evidence demonstrates a complete tissue renin-angiotensin system (RAS) within the kidney that plays many roles in the control of the intrarenal vasculature, as well in the control of glomerular and tubular processes (1). Substantial clinical and experimental data suggest that the intrarenal RAS is important, if not central, to the development and progression of diabetic nephropathy. Given the major impact of diabetic nephropathy on the health of diabetic individuals, to say nothing of health costs, alterations in the intrarenal RAS in diabetes have been of great interest, particularly given the demonstrated clinical benefit of blocking the RAS on the development and progression of diabetic nephropathy (2).

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome