Mechanism of Injury in Uromodulin-Associated Kidney Disease

[摘要] Nephronophthisis (NPHP), medullary cystic kidney disease (MCKD), and familial juvenile hyperuricemic nephropathy (FJHN) are three renal disorders with overlapping clinical features. Recent molecular genetic studies have begun to clarify the similarities and differences between these conditions. Moreover, the pathogenetic mechanisms of renal damage in these conditions are being clarified. In this issue of JASN, Jennings et al. (1) present one such study.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome