This Month's Highlights

[摘要] After acute renal injury, bone marrow cells infiltrate the kidney and convert into renal cells. Using two different methods of detection, Li et al. demonstrate that some bone marrow cells undergo this conversion by fusing with injured renal cells after ischemia-reperfusion injury. The low frequency of fusion, approximately 7 per 10,000 tubular cells, however, suggests that the majority of bone marrow cells become renal cells by other mechanisms. If alternative mechanisms are identified, then future therapies for acute kidney injury could incorporate methods to promote bone marrow cell conversion into tubular epithelial cells. See Li et al., pages 3067–3077.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome