Chronic Transplant Glomerulopathy: Need for Further Assessment

[摘要] Chronic transplant glomerulopathy (CTG), investigated in a large single-center study by Akalin et al. (1), is an interesting pathologic lesion that develops in the renal allograft. It is characterized by endothelial cell injury or loss, accumulation of flocculent material in a widened subendothelial space, and mesangial interposition with deposition of new matrix along glomerular capillary walls. These progressive changes produce a thickened glomerular capillary profile and the capillary wall “double contours” that are demonstrable on periodic acid-Schiff and silver staining and that define CTG (2). Analogous changes occur in later stages of thrombotic microangiopathy (TMA) in the native kidney, initiated by endothelial injury and/or dysfunction. Development of this lesion in the renal allograft has been associated with worse graft outcome.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome