Novel Approaches in the Investigation of Acute Kidney Injury

[摘要] Acute kidney injury (AKI) remains a significant health care concern. Many reports describe high mortality rates that largely have remained unchanged for several decades (1,2). With such a poor prognostic outlook, scientists have sought to develop novel therapies that are based on information gleaned from clinical studies as well as in vitro and in vivo models of renal injury. These approaches have been geared toward understanding molecular, cellular, and physiologic responses of renal injury and have led to a focus on pathways that are related to metabolism, oxidant stress, hemodynamics, inflammation, and growth factors, to name a few, as potential targets of therapy (3).

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome