This Month’s Highlights

[摘要] Diuretics are typically secreted into the late proximal tubule and have their effects at the luminal surface of downstream segments of the nephron. The basolateral transporters in the late proximal tubule have been identified as organic anion transporters, and the transport steps across the apical membrane of the proximal tubule have been attributed to members of the ATP-binding cassette (ABC) family of transporters. Hasegawa et al. investigated the functional significance of two ABC proteins (MDR4 and BCRP) with knockout mouse models. Renal clearance of furosemide and hydroclorothiazide was significantly reduced in the MDR4 knockouts, but not in the BCRP knockouts. The inhibition in the MDR4 knockout was not complete, which suggests that other transporters are also involved. The broad substrate specificity of MDR4 also suggests that there could be competitive effects between diuretics and other ligands at the apical secretory step in the proximal tubule. See Hasegawa et al., pages 37–45.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome