Uroguanylin: Physiological Role as a Natriuretic Hormone

[摘要] A research group from Miyazaki, Japan, previously demonstrated that the nephrotic syndrome is associated with increased levels of uroguanylin (1). Kikuchi et al. return to the topic in this issue of JASN with a report that a model of nephrosis, which was induced in rats by treatment with puromycin, also causes marked perturbations in the levels of circulating and urinary uroguanylin. To most nephrologists, the primary questions that come to mind will be: What is uroguanylin and why do pathophysiological changes in a gut-derived peptide occur in nephrosis?

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome