V2 Receptor Antagonists in Cystic Kidney Diseases: An Exciting Step towards a Practical Treatment

[摘要] It is unusual in nephrology for the fruits of basic science research in genetics and cell biology to directly translate into a practical therapy for common renal diseases. Therefore it is with great anticipation that the clinical and research communities receive publications like the article by Wang et al. in this issue of the Journal of the American Society of Nephrology, which shows striking efficacy of a nonpeptide selective vasopressin 2 (V2) receptor antagonist in a rat model of autosomal recessive polycystic kidney disease (ARPKD) (1).

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome