Which Comes First—Renal Dysfunction or High Blood Pressure? Elevated Blood Pressure and Risk of End-Stage Renal Disease in Subjects without Baseline Kidney Disease. Arch Intern Med 165: 923–928, 2005

[摘要] It had been known since the early days of Franz Volhard (1) and Arthur Fishberg (2) that renal disease and renal failure occur commonly in hypertensive patients. In the study of Perera (3), at a time when antihypertensive medication had not yet become available, a large proportion of patients with essential hypertension wound up in renal failure. This was later ascribed to the occurrence of malignant hypertension. With the advent of effective antihypertensive medication, malignant hypertension has become much rarer. In relatively short-term trials that clearly documented the cardiovascular benefit from antihypertensive medication, few if any cases with renal failure were observed. This led to an as yet unresolved dilemma.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome