This Month's Highlights

[摘要] The administration of oxytocin to induce labor in pregnancy is associated with hyponatremia, but the mechanisms underlying the retention of water are incompletely understood. Li et al. infused oxytocin for 5 d into vasopressin-deficient rats and observed that oxytocin acts through vasopression (V2) receptors on the principal cells of the collecting duct to increase the expression and trafficking of aquaporin-2 and aquaporin-3. These results raise the intriguing possibility of treating severe oxytocin-induced hyponatremia with V2 receptor antagonists, which would not affect oxytocin-mediated uterine contractions. See Li et al., pages 225–232.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome