Care of the Kidney Transplant Recipient

[摘要] Kidney transplantation is a successful treatment modality for end-stage real disease and the preferred mode of renal replacement therapy. Both patient and allograft survival at 1 yr are >90% in most transplant centers. The success of transplantation has in fact led to an increased demand for organs and an increased waiting time for deceased donor kidneys. This in turn has stimulated increased living donation and the use of extended-criteria deceased donor kidneys, including those donated after cardiac death. Moreover, although more potent and complex immunosuppressive strategies have reduced the rates of acute rejection and improved short-term graft survival, long-term graft survival rates have not improved as dramatically. This is due in part to continued graft failure caused by allograft fibrosis and atrophy (also known as chronic allograft nephropathy or CAN) as well as death with a functioning graft. Transplant nephrologists are now focusing on the medical management of their patients with more attention to the details of the medical management of comorbidities. Thus, this supplement of the Clinical Journal of the American Society of Nephrology will explore the leading medical complications after kidney transplant, with attention to etiology, detection, and management.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome