Sequestration and Suppression of Anti-HLA Antibodies by a Failed Kidney Allograft

[摘要] Nephrectomy of a failed kidney transplant is indicated for hematuria and local pain (usually attributed to rejection), but may be done electively to facilitate cessation of immunosuppression. Transplant nephrectomy may also limit long-term cardiovascular risk (1). Despite these potential benefits, transplant nephrectomy can be complicated by morbidities surrounding surgery, and several retrospective reports suggest that nephrectomy is associated with an increase in circulating anti-HLA antibodies (1–6). The enduring implications of the latter are significant because anti-HLA antibodies confer both an increase wait time for retransplantation and elevated risk for subsequent graft failure (7,8).

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome