Albuminuria and Cognitive Impairment

[摘要] There is a high prevalence of cognitive impairment and dementia in individuals with ESRD. It has been proposed that the high prevalence of cognitive impairment is related to cerebrovascular disease, and the pattern of cognitive impairment is consistent with vascular dementia (1). Individuals with CKD have an increased risk of white matter changes and subclinical strokes, which are findings associated cognitive impairment (2,3). Whether mild CKD, in particular albuminuria, is associated with cognitive decline has been less well studied. In this issue, Sajjad et al. (4) evaluate albuminuria and estimated GFR (eGFR) with cognitive decline in a longitudinal analysis of the Nurse's Health Study, a cohort study of registered nurses. Cognitive testing, plasma creatinine, and urine albumin/creatinine ratio were available in a subset of individuals. Cognitive testing was repeated every 2 years and included a battery of six tests.

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome