Correction

[摘要] Pickering JW, Endre ZH: New Metrics for Assessing Diagnostic Potential of Candidate Biomarkers. Clin J Am Soc Nephrol 7: 1355–1364, 2012; published ahead of print June 7, 2012, doi:10.2215/CJN.09590911. In this paper, we wrote “The NRI is the sum of NRIevents and NRInonevents. It is interpreted as the proportion of patients reclassified to a more appropriate risk category.” Dr. Kathleen Kerr of the University of Washington and Dr. Margaret Pepe of the University of Washington and Fred Hutchison Cancer Research Center have kindly pointed out to us that the NRI is not a proportion; rather, it is a combination of four proportions. Therefore, we would like to clarify the interpretation of the metrics: NRIevents is the difference in two proportions, namely the proportion of patients with events moving to a higher-risk category minus the proportion with events moving to a lower-risk category. That is, the NRIevents is the net proportion, with events reclassified to a more appropriate risk category. If NRIevents is negative, this indicates more patients with events have moved to a lower-risk category rather than a higher-risk category. The NRInonevents is also the difference in two proportions, namely the proportion of patients without events moving to a lower-risk category minus the proportion without events moving to a higher-risk category and may be interpreted as the net proportion, without events reclassified to a more appropriate risk category. If NRInonevents is negative, more patients without the event have moved to a higher-risk category than have moved to a lower-risk category [see the equations in the Appendix of our article and in the original article of Pencina et al. (1)].

[学科分类] 泌尿医学

[关键词] Bone marrow necrosis;Sickle cell disease;Hyperhemolysis syndrome