A New Look at Two Old Topics

[摘要] The studyIn a rigorous retrospective analysis of 2090 patients admitted with acute osteomyelitis to 36 children’s hospitals from 2009 to 2012, treatment failure and adverse outcomes were compared between those receiving postdischarge peripherally inserted central catheter (PICC) versus oral antibiotic therapy. The authors used propensity scores and complex modeling to control for severity, organism, infection location, child age, and hospital, along with statistical techniques (stratified and marginal modeling) to approximate a randomized controlled trial. Cases culled from the Pediatric Health Information System database were validated with individual chart review and data enhanced.#### The key findingsTreatment failure rates both across and within hospitals were similar for children with acute osteomyelitis discharged on PICC and oral antibiotics, irrespective of child age or organism. Odds of adverse outcomes, including drug reactions, emergency department visits, and complications, were significantly …

[学科分类] 儿科学

[关键词] Campylobacter;proljev;dob