Discusses the major design considerations necessary in the successful construction of precast, prestressed concrete building structures situated in seismic areas. The importance and interaction of stiffness, strength, toughness and, especially, fail-safe connections are emphasized. Such connections are needed not only to transfer loads but to provide continuity and overall monolithic behavior in the entire structure. Suggestions are given on how to increase the stiffness of the structure as well as advice on good and poor design practices. Examples of precast concrete buildings drawn from the author's 40 years design experience are shown and commented upon.