This paper presents results of a structural analysis and a preliminary design of a precast prestressed concrete lunar base subjected to one atmospheric internal pressure. The proposed infrastructure measures 120 ft (36.6 m) in diameter and 72 ft (22 m) in height, providing 33,000 sq ft (3060 m2 ) of work area for scientific and industrial operations. Three loading conditions—during construction, under pressurization, and during an air leak scenario—were considered in the design. A floating foundation, capable of rigid body rotation and translation as the lunar soil beneath it yields. was developed o support the infrastructure and to ensure the air tightness of the system. Results reveal that it is feasible to use precast prestressed concrete for construction of large lunar bases on the moon.