Inelastic seismic responses of precast concrete frames and their monolithic counterparts are calculated to evaluate the effect of semi-rigid connections on the seismic behavior of multistory precast frames. Fixity factors defined for precast beam-to-column connections are used as variables in the analytical investigation. It is concluded that the differences between the seismic behaviors of precast and monolithic concrete frames are not significant, provided that the fixity factors remain above 0.80. Strong column-weak beam design plays an important role in reducing these differences. However, it may be necessary to consider the connection rigidity as a design parameter, unless rigid connection behavior is ensured.