An experimental investigation was conducted to evaluate the behavior and strength of bridges constructed with full-span prestressed concrete form panels. This paper addresses the behavior under repeated service loadings and ultimate strength of this type of bridge. Two full-scale specimens were fabricated and subjected to 5 million cycles of service loading before being loaded to failure. It was concluded that these composite bridges will perform adequately under repeated service loadings when composite action between the precast panels and a cast-in-place topping is achieved by applying a raked finish to the precast panels. The full design moment capacities were developed in each specimen after the 5 million cycles of service load had been applied. These ultimate capacities were found to be independent of he moments induced by the restraint of time-dependent deformations.