This paper presents the results of a study of the horizontal shear resistance of the connection between full-depth precast concrete bridge deck panels and prestressed concrete girders. This connection consists of isolated shear connectors extending from the precast I-girder into a block-out pocket in the precast deck panel. The block-outs and the haunch between the panel and the beam are grouted. To investigate the strength and behavior of the connections, 36 push-off tests were performed. The primary parameters investigated were type of grout, haunch height, and area of reinforcing steel crossing the interface. In addition, several alternate shear connector details were tested. it was concluded that of currently known horizontal shear resistance equations, the one presented in the AASHTO LRFD Bridge Design Specifications is the best predictor of the strength of the specimens.