Two commercially available carbon fiber reinforced polymer (CFRP) prestressing systems were compared for use in continuous prestressed concrete bridges in this investigation. Two two-span double-tee (DT) continuous bridge models were fabricated, instrumented, and tested. The two bridge models were identical except that Bridge Model CDT1 was pretensioned and posttensioned with the CFRP LeadlineTM tendon system, whereas the carbon fiber composite cable (TCFMCC) system was used in Bridge Model CDT2. The study examined parameters such as midspan deflections, concrete strains, and posttensioning forces in externally draped strands/tendons under static loading and 15 million cycles of repeated loads. The ductility, failure modes, load carrying capacities, and posttensioning tendon forces of both bridge models were compared by conducting an ultimate load test. The responses of both bridge models were almost identical, except for the failure mode and the ductility index.