Synthesis of Furfural Derivatives (). Oxime Formation of 2-Furfural and Some 5-Substituted Furfurals

[摘要] The rate of oxime formation of 2-furfural and 5-substituted-2-furfurals such as 5-methyl-2-furfural, 5-isopropyl-2-furfural, 5-tert-butyl-2-furfural, 5-isoamyl-2-furfural and 5-nitro-2-furfural have been measured at 15¡­45¡É in aqueous solution buffered at pH 7. Oxime formation for all the compounds investigated is second-order reaction and their activation energies observed are 5.50, 7.22, 7.03, 7.49, 7.78 and 4.97 kcal/mole, respectively. Hammett equation is obtained for 5-alkyl-2-furfurals and the reaction constants (¥ñ) calculated at 15, 25, 35 and 45¡É are 2.010, 1.756, 1.541, and 1.311 respectively.

[学科分类] 化学（综合）