Peptide-Water Interaction. Effects of Pressure and Temperature on the Solubility of 1-Phenyl-2-acetamido-3-butanone

[摘要] The solubilities of 1-phenyl-2-acetamido-3-butanone were measured in H2O at 20, 30 and 40¡É at pressure from 1 to 4500 kg/cm2. Pressure going up to 4500 kg/cm2, the solubility in H2O decreases consistantly as that of diketopiperazine does. As diketopiperazine is a model compound of peptide bond and 1-phenyl-2-acetamido-3-butanone has only one peptide bond and a pretty large hydrophobic group, the solubility behavior is quite surprising. Volume change and heat capacity change data are reasonable.

[学科分类] 化学（综合）