Photochemical Synthesis of Phenylglycine

[摘要] Phenylacetic acid is chlorinated photochemically in carbon disulfide and carbon tetrachloride solvents to obtain ¥á-chlorophenylacetic acid in 43% yield (after separation and purification). The amination of ¥á-chlorophenylacetic acid yielded the desired dl-phenylglycine in 16¡­27% yield depending on the solvent used. Sensitized photophenylation of glycine is also attempted utilizing benzoylperoxide as a phenyl radical source in benzene or acetone solvent.

[学科分类] 化学（综合）