At least two genes found in the genome of Asterias rubens after immunizations to the antigen Horse-Radish Peroxydase(HRP), could play the role ofoncologic markers: The first one (Igkappa chain V-V region T 1 S 107 B precursor) reveals myeloma; The second (B cell CLL/Lymphoma 9-like) as the first one has a kinship to the IgKappa gene subfamily.