G proteins, one of the most important transmembrane signal transducers, contain four subfamilies. G?q is the ? subunit of Gq protein subfamily. The G?q containing protein initially attracted attention for its physiological significance is in cardiovascular system. In recent years, its role in immune regulation has been indicated. Studies domenstrated that G?q plays crucial role in regulating both innate and adaptive immune cells function and it is involved in the development of autoimmune disease. In this review, we summarized recent data in the role of G?q containing protein in regulating immune cells function and the possible mechanisms.
