Gamnamoside, a Phenylpropanoid Glycoside from Persimmon Leaves (Diospyros kaki) with an Inhibitory Effect against an Alcohol Metabolizing Enzyme

[摘要] Phytochemical investigation of the methanolic extract of Diospyros kaki leaves led to the isolation of osmanthuside H (1) and a new phenol glycoside, named gamnamoside [4-(3-hydroxypropyl)-2-methoxyphenol �?-D-apiofuranosyl( 1 �? 6)�?-D-glucopyranoside] (2) along with (-) catechin (3) through a series of reversed phase column chromatography and preparative C₁₈ HPLC. The structures of the isolates were determined by spectroscopic methods including IR, UV, HRTOFMS, and 2D NMR. Compounds 1, 2, and 3, showed good inhibitory activities (IC₅₀) of 175.4, 94.4, and 126.6 レg/mL respectively, whereas a reversible ADH inhibitor, 4-methylpyrazole, showed the IC₅₀ of 326.6 レg/mL against alcohol dehydrogenase (ADH).

[学科分类] 化学（综合）

[关键词] Persimmon;Diospyros kaki;Gamnamoside;(-) Catechin;Alcohol dehydrogenase