Preparation and Application of a New HPLC Chiral Stationary Phase Derived from 2-Amino-1-indanol

[摘要] A new chiral stationary phase (CSP) based on (1R,2S)-2-amino-1-indanol, which is expected to be conformationally rigid because of its cyclic nature, was prepared. The new CSP was applied in resolving various N-acyl-�?-arylalkylamines. The chromatographic resolution results on the new CSP were compared with those on the other CSP based on (1S,2R)-norephedrine, which is believed to be conformationally flexible. Comparison of the chromatographic resolution results on the two CSPs demonstrated that conformationally flexible analytes are resolved better on the conformationally rigid CSP while conformationally rigid analytes are resolved better on the conformationally flexible CSP. From these results it was concluded that conformational rigidity or flexibility of CSPs is the important factor for the chiral recognition.

[学科分类] 化学（综合）

[关键词] Chiral stationary phase;Enantiomer separation;Liquid chromatography;2-Amino-1-indanol.