The Opioid Rotation Ratio of Hydrocodone to Strong Opioids in Cancer Patients

[摘要] Results. Overall, 170 patients underwent OR from hydrocodone to stronger opioid. The median age was 59 years, and 81% had advanced cancer. The median time between OR and follow-up was 21 days. We found 53% had a successful OR with significant improvement in the ESAS pain and symptom distress scores. In 100 patients with complete OR and no worsening of pain at follow-up, the median ORR from hydrocodone to MEDD was 1.5 (quintiles 1�?3: 0.9�?2). The ORR was associated with hydrocodone dose (r = �?.52; p < .0001) and was lower in patients receiving �?40 mg of hydrocodone per day (p < .0001). The median ORR of hydrocodone to morphine was 1.5 (n = 44) and hydrocodone to oxycodone was 0.9 (n = 24).

[学科分类] 肿瘤学