A Prospective Study of Shortened Vitamin Supplementation Prior to Cisplatin–Pemetrexed Therapy for Non-Small Cell Lung Cancer

[摘要] Results. Thirty patients received chemotherapy starting within 48 hours of the vitamin B₁₂ injection. No treatment-related deaths or grade 4 toxicity occurred. Neutropenia grade �?3, other laboratory toxicities grade �?3, and nonlaboratory toxicities grade �?3 occurred in 6.7%, 13%, and 13% of patients, respectively. The baseline homocysteine concentrations were not higher in patients with grade �?3 toxicities than in the remainder of the cohort (mean values, 8.6 and 10.7 μmol/L, respectively). The response rate to chemotherapy was 43%.

[学科分类] 肿瘤学