Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine

[摘要] ESCs �? embryonic stem cells; iPSCs �? inducedpluripotent stem cells; Chd1 �? chromodomain helicase DNA-binding protein; BAF �?rg/Brahma-associated factors; miRNA, miR �? microRNA; TERRA �?telomeric-repeat-containing RNA; Cdkn �? cyclin-dependent kinase inhibitor; VPA�? valproic acid; siRNA �? small interfering RNA; KMOS �? Klf4, c-Myc, Oct4, Sox2;KOS �? Klf4, Oct4, Sox2; LNOS �? Lin28, Nanog, Oct4, Sox2; GSK-3 �? glycogensynthase kinase 3; ROS �? reactive oxygen species; HIF1 �? hypoxia-induciblefactor 1; VEGF �? vascular endothelial growth factor.

[学科分类] 生物技术

[关键词] cell reprogramming;induced pluripotent stem cells;directed stem cell differentiation;cell replacement therapy