Promoters with Cancer Cell-Specific Activity for Melanoma Gene Therapy

[摘要] Ad �? adenovirus; CRAds �? conditionally replicative adenoviruses; DT-A �? diphtheria toxin A chain; HSVtk �? herpes simplex virus thymidine kinase; SCLC �? small cell lung cancer; MC1R �? melanocortin 1 receptor; MIA �? melanoma inhibitory activity, MITF �? microphthalmia-associated transcription factor; TERT �? human telomerase reverse transcriptase; TSP �? tumor specific promoter; TSS �? transcription start site

[学科分类] 生物技术

[关键词] melanoma;gene therapy;tissue-specific promoters;specific expression of a transgene