Mechanisms of Activation of Voltage- Gated Potassium Channels

[摘要] Kv – voltage-gated potassium channel; aa – amino acid residue; VSD, voltage-sensing domain; SHM – sliding-helix model; TM – transport model; PM, paddle model; CMH, model of coordinated movement of helices; CM – consensus model; MCT – model of charge transfer; MKD – model of Kv deactivation; MMd – mechanistic model of Kv activation/deactivation; FRET – Förster resonance energy transfer; MM – molecular modeling; СTС – charge transfer center, MD – molecular dynamics; GC – gate channel.

[学科分类] 生物技术

[关键词] activation;potassium ion channels;modeling;structure.