MICROBIOLOGICAL TRANSFORMATIONS OF PROGESTERONE

[摘要] Transformation of progesterone by various microorganisms such as actinomycetes, yeast and mould fungi of different 53 strains had been studied. 19 different strains was able to oxygenate progesterone at C11. The transformation products, other than 11α-hydroxyprogesterone, which were formed by these active strains had been identified. These studies proved that the active organisms were capable of introduction of oxygen function at different positions other than position 11 of progesterone e.g. positions 17 and 21. Side chain degradation reaction with and without lactone formation of ring D of progesterone had been also found to be performed by some of these organisms.

[学科分类] 微生物学和免疫学