Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713

[摘要] Screening for NADH-fumarate reductase inhibitors led to the isolation of a new ukulactone analog, ukulactone C, as a major polyene compound produced by Talaromyces sp. FKI-6713. The structure of the compound was elucidated as a reduced analog of ukulactone A by 1D- and 2D-NMR experiments. Ukulactone C possessed a potent inhibitory activity (IC50 = 62 nM) against NADH-fumarate reductase of the roundworm Ascaris suum in vitro.

[学科分类] 微生物学和免疫学

[关键词] electron transport enzyme inhibitor;NADH-fumarate reductase;Talaromyces;ukulactone