STUDIES ON THE MECHANISM OF PROGESTERONE TRANSFORMATION WITH RHIZOPUS NIGRICANS

[摘要] Various enzymic transformation of progesterone with Rhizopus nigricans REF. 129 was studied by allowing the fermentation to proceed at different time intervals ranging from 2 to 192hr. The monohydroxylated compounds, 11α-, 17α-, and 21-hydroxyprogesterone, were formed at the early stage of fermentation. Later on, 11α-hydroxyallopregnane, followed by 6β, 11α, dihydroxyprogesterone, and then 11α, 17α-dihydroxy derivative and epicortisol were detected.Different derivatives of progesterone were used as substrates in a trial to investigate the pathways of progesterone transformation by the experimental organism. A scheme is put forward summarizing these reactions.

[学科分类] 微生物学和免疫学