Towards fast and accurate temperature mapping with proton resonance frequency-based MR thermometry

[摘要] The capability to image temperature is a very attractive feature of MRI and has been actively exploited for guiding minimallyinvasivethermal therapies. Among many MR-based temperature-sensitive approaches, proton resonance frequency (PRF)thermometry provides the advantage of excellent linearity of signal with temperature over a large temperature range.Furthermore, the PRF shift has been shown to be fairly independent of tissue type and thermal history. For these reasons,PRF method has evolved into the most widely used MR-based thermometry method. In the present paper, the basicprinciples of PRF-based temperature mapping will be reviewed, along with associated pulse sequence designs. Technicaladvancements aimed at increasing the imaging speed and/or temperature accuracy of PRF-based thermometry sequences,such as image acceleration, fat suppression, reduced field-of-view imaging, as well as motion tracking and correction, willbe discussed. The development of accurate MR thermometry methods applicable to moving organs with non-negligible fatcontent represents a very challenging goal, but recent developments suggest that this goal may be achieved. If so, MR-guidedthermal therapies may be expected to play an increasingly-important therapeutic and palliative role, as a minimally-invasivealternative to surgery.KeywordsThermometry; focused ultrasound (FUS) thermal therapy; proton resonance frequency (PRF); temperature mapping; pulse sequence; motion

[学科分类] 外科医学

[关键词] Thermometry;focused ultrasound (FUS) thermal therapy;proton resonance frequency (PRF);temperature mapping;pulse sequence;motion