Label-free imaging of blood vessel morphology with capillary resolution using optical microangiography

[摘要] Several tissue pathologies are correlated with changes in the blood vessel morphology andmicrocirculation that supplies the tissue. Optical coherence tomography (OCT) is an imaging technique thatenables acquiring non-invasive three-dimensional images of biological structures with micrometer resolution.Optical microangiography (OMAG) is a method of processing OCT data which enables visualizing thethree-dimensional blood vessel morphology within biological tissues. OMAG has high spatial resolutionwhich allows visualizing single capillary vessels, and does not require the use of contrast agents. The intrinsicoptical signals backscattered by the moving blood cells inside blood vessels are used as the contrast for whichOMAG images are based on. In this paper, we discuss a brief review of the OMAG theory, and present someexamples of applications for this technique.

[学科分类] 外科医学