Aristolochia manantlanensis Santana-Michel is described as new species in subsecction Pentandrae Duchr., from San Miguel in the Sierra de Manantlán Biosphere Reserve. This species grows with Zea diploperennis Iltis, Doebley & Guzmán, and by morphological characters it is related to A. acontophylla Pfeifer, A. karwinskii Duchr. and A. variifolia Duchr.