Polygonum nepalense Meisn. (= Persicaria nepalensis (Meisn.) H. gross), Polygonaceae, of Asia is reported as new to Mexico. Two populations were found in highaltitude areas of the State of Mexico, and they appear to be in expansion. The species is known as an aggressive weed, with high impact on various crops, and also as an invader of natural vegetation. As the invasion seems to be recent and incipient, an eradication effort is recommended.