Left ventricular function plays a role in cognitive ageing

[摘要] Ageing affects and is also being affected by various physiological processes in the human system, in particular the brain [1, 2]. In patients with severe cardiomyopathies, left ventricular ejection fraction (LVEF) is related to abnormal brain ageing, including cognitive impairment, structural neuroanatomical abnormalities, and increased risk for Alzheimer’s disease. Cognitive impairment diminishes and cerebral blood flow increases by more than 50% after heart transplantation because of improvement in cardiac function. Therefore, a reduced LVEF may influence cerebral perfusion homeostasis and contribute to clinical brain injury.

[学科分类] 心脏病和心血管学