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Captopril Enhances Cardiac Vagal but Not Sympathetic Neurotransmission in Pithed Rats
[摘要] References(15)Cited-By(3)The effect of captopril on neurally evoked bradycardia and tachycardia was investigated in pithed rats. Captopril enhanced the vagal nerve stimulation-evoked bradycardia. Angiotensin I reduced the vagal bradycardia, which was reversed by subsequent administration of captopril. Bradykinin did not affect the neurally evoked bradycardia. Captopril and angiotensin I affected neither the exogenous acetylcholine-evoked bradycardia nor the sympathetic nerve stimulation-evoked tachycardia. These results suggest that the interruption of angiotensin II formation by captopril causes less presynaptic inhibition of acetylcholine release via angiotensin II receptors without affecting cardiac sympathetic neurotransmission.
[发布日期]  [发布机构] 
[效力级别]  [学科分类] 药学
[关键词] captopril;autonomic neurotransmission;rat heart [时效性] 
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