Polysaccharide Extract Isolated From Ganoderma lucidum Protects Rat Cerebral Cortical Neurons From Hypoxia/Reoxygenation Injury
[摘要] References(15)Cited-By(19)The effect of polysaccharide extract isolated from Ganoderma lucidum (Gl-PS) on rat cortical neuronal cultures exposed to hypoxia/reoxygenation (H/R) was studied in vitro. Gl-PS (1, 10, 100 μg/ml) increased neuron viability following H/R as measured by the inhibition of MTT reduction. Gl-PS also significantly reduced malondialdehyde content and reactive oxygen species production and increased the manganese superoxide dismutase (Mn-SOD) activity; furthermore, the translocation of nuclear factor-kappa B induced by H/R was blocked. These findings suggest that Gl-PS might be useful in treating H/R-induced oxidative stress and Mn-SOD might play a critical role in the neuroprotective effect of Gl-PS against H/R injury.
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[效力级别] [学科分类] 药学
[关键词] polysaccharide extract isolated from Ganoderma lucidum;cultured rat cortical neuron;hypoxia/reoxygenation [时效性]