Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice

[摘要] References(21)Cited-By(6)We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and the infracted size was significantly smaller in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury, and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.

[学科分类] 药学

[关键词] Na+/Ca2+ exchanger (NCX);knockout mouse;heart;ischemia/reperfusion injury