Involvement of the Long-Chain Fatty Acid Receptor GPR40 in Depression-Related Behavior

[摘要] References(16)Cited-By(3)The functional role of brain G protein–coupled receptor 40 (GPR40) remains unclear. We investigated GPR40 signaling in depression-related behavior in mice via the forced swim test. A repeated but not a single intracerebroventricular administration of the GPR40 agonist, GW9508, reduced the duration of immobility behavior. Moreover, the levels of hippocampal non-esterified docosahexaenoic acid and arachidonic acid were decreased immediately after the forced swimming. These results suggested that brain GPR40 signaling may regulate depression-related behavior.

[学科分类] 药学

[关键词] G protein–coupled receptor 40;depression;free fatty acid