Topics on the Na+/Ca2+ Exchanger:Role of Vascular NCX1 in Salt-Dependent Hypertension

[摘要] References(40)Cited-By(7)Excess salt intake is a major risk factor for hypertension. However, the molecular mechanisms underlying salt-dependent hypertension remain obscure. Our recent studies using selective Na+/Ca2+ exchange inhibitors and genetically engineered mice provide compelling evidence that salt-dependent hypertension is triggered by Ca2+ entry through Na+/Ca2+ exchanger type 1 (NCX1) in arterial smooth muscle. Endogenous cardiac glycosides, which may contribute to salt-dependent hypertension, seem to be necessary for NCX1-mediated hypertension. Intriguingly, recent studies by Dostanic-Larson et al. using knock-in mice with modified cardiac glycoside binding affinity of Na+,K+-ATPases demonstrate that this binding site plays an important physiological role in blood pressure control. Thus, when cardiac glycosides inhibit Na+,K+-ATPase in arterial smooth muscle cells, the elevation of local Na+ on the submembrane area is believed to facilitate Ca2+ entry through NCX1, resulting in vasoconstriction. This proposed pathway may have enabled us to explain how to link dietary salt to hypertension.

[学科分类] 药学

[关键词] salt-dependent hypertension;Na+/Ca2+ exchanger type 1 (NCX1);SEA0400;endogenous ouabain;Na+;K+-ATPase