Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
[摘要] References(15)Cited-By(1)The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral NG-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the α- and β-chains of fibrinogen, whereas plasma NO2− level and hepatic expression of endothelial NOS (eNOS) mRNA were significantly decreased. These results suggest that L-NAME treatment can increase plasma fibrinogen levels via an increase in expression of fibrinogen mRNA in the liver, and NO may be involved in plasma fibrinogen increase.
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[效力级别] [学科分类] 药学
[关键词] fibrinogen;NG-nitro-L-arginine-methyl ester;mRNA [时效性]