Pathophysiological Significance of T-type Ca2+ Channels:T-type Ca2+ Channels and Drug Development

[摘要] References(61)Cited-By(17)T-type Ca2+ channels are present in cardiovascular, neuronal, and endocrine systems; and they are now receiving attention as novel therapeutic targets. Many drugs and compounds non-specificaly block T-type Ca2+ channels. Certain dihydropyridine compounds, such as efonidipine, have blocking activity on both L-type and T-type Ca2+ channels which possibly underlies their excellent clinical profiles such as minimum reflex tachycardia and renal protection. Selective inhibitors of T-type Ca2+ channels, such as non-hydrolyzable mibefradil and R(−)-efonidipine, are powerful pharmacological tools for further studies and may lead to the development of novel therapeutic strategies.

[学科分类] 药学

[关键词] T-type Ca2+ channel;sino-atrial node;pacemaking;dihydropyridine;efonidipine