Monitoring Expression of Cytochrome P450 Genes During Postischemic Rat Liver Reperfusion Using DNA Microarrays

[摘要] References(10)Cited-By(4)We investigated the expression of 50 cytochrome P450 (CYP) genes in the postischemic reperfused rat liver using a DNA microarray. Thirteen CYPs showed absent expression in all experiments and 2 CYPs were induced by pentobarbital, which was used as an anesthetic. Eight of the remaining 35 CYPs showed significantly decreased expression following ischemia-reperfusion. Monitoring CYP expression may be a powerful approach for elucidation of pathways regulating drug metabolism that may be involved in postischemic reperfusion liver injury.

[学科分类] 药学

[关键词] cytochrome P450;postischemic liver reperfusion;gene expression