已收录 273075 条政策
 政策提纲
  • 暂无提纲
Aminophylline Pretreatment Modulates the Nitric Oxide System of the Isolated Rat Diaphragm: the Role of Frequency of the Electrical Stimulation
[摘要] References(15)Cited-By(2)The effect of different frequencies of direct subtetanic electrical stimulation (14, 20, and 30 Hz) and aminophylline (AMPh) pretreatment on the effect of NG-nitro-L-arginine methyl ester (L-NAME) (1 mM) on isolated rat diaphragm was investigated. L-NAME potentiated tension developed (Td) in the diaphragm pretreated with a single concentration of AMPh (1.08 mM) in a frequency-dependent manner. The effect was significantly different in comparison with muscle incubated 30 min with Tyrode solution only. In the muscle pretreated with cumulative concentrations of AMPh (0.36 - 3.60 mM), the frequency-dependent potentiation of Td induced by L-NAME and the difference between L-NAME-treated and untreated muscle were lost.
[发布日期]  [发布机构] 
[效力级别]  [学科分类] 药学
[关键词] aminophylline;NG-nitro-L-arginine methyl ester;stimulation frequency [时效性] 
   浏览次数:2      统一登录查看全文      激活码登录查看全文